Common mistakes around TSH Genetik

Common mistakes around TSH genetics: Many assume a DNA test can predict thyroid function. In reality, TSH-associated variants (e.g., in PDE8B, CAPZB) have small effects, explaining <5% of TSH variation. Commercial tests often exaggerate their predictive power. TSH levels fluctuate with time of day, diet, stress, and medications. A genetic finding does not replace clinical thyroid labs (TSH, fT3, fT4, antibodies). Also, 'risk variants' are often misinterpreted – many people with them have normal TSH. Evidence: human-moderate (GWAS, population studies). Caveat: No clinical recommendation exists for single variants.