Evidence check: FADS1 in the context of Haut

Evidence for FADS1 variants (e.g., rs174547) in skin health is moderate. FADS1 encodes delta-5 desaturase, crucial for omega-3/6 fatty acid conversion, affecting skin barrier function and inflammation. GWAS and observational studies link certain alleles to atopic dermatitis, dry skin, and eczema, especially with dietary interactions. However, effect sizes are small and population-dependent. Consumer DNA tests (e.g., MyBody-X) may report FADS1, but predictive value is limited. Skin health is multifactorial; genetics alone cannot guide interventions. Evidence grade: human-moderate. No safety concerns, but do not base medical decisions on this result alone.