{"count":4,"index":{"built_at":"2026-07-27T06:54:11.195088+00:00","public_records":55311,"revision":"bb8d3a56e01dcdc52179f664"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: FADS1 in the context of Haut"},"results":[{"answer":"Evidence for FADS1 variants (e.g., rs174547) in skin health is moderate. FADS1 encodes delta-5 desaturase, crucial for omega-3/6 fatty acid conversion, affecting skin barrier function and inflammation. GWAS and observational studies link certain alleles to atopic dermatitis, dry skin, and eczema, especially with dietary interactions. However, effect sizes are small and population-dependent. Consumer DNA tests (e.g., MyBody-X) may report FADS1, but predictive value is limited. Skin health is multifactorial; genetics alone cannot guide interventions. Evidence grade: human-moderate. No safety concerns, but do not base medical decisions on this result alone.","area":"gesundheit","canonical_id":"gesundheit:canonical-9d43f6bab487a18bf54af26d","id":"public-a28708bbedd9e2fa3bb356f1","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: FADS1 in the context of Haut","score":22.22340757,"snippet":"Evidence for FADS1 variants (e.g., rs174547) in skin health is moderate. FADS1 encodes delta-5 desaturase, crucial for omega-3/6 fatty acid conversion, affecting skin barrier function and inflammation. GWAS and observational studies link certain alleles to atopic dermatitis, dry skin, and eczema, especially with dietary interactions. However, effect sizes are small and population-dependent. Consumer DNA tests (e.g., MyBody-X) may report FADS1, but predictive value is limited. Skin health is multifactorial; genetics alone cannot guide interventions. Evidence grade: human-moderate. No safety concerns, but do not base medical decisions on this result alone.","sources":[],"title":"Evidence check: FADS1 in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-a28708bbedd9e2fa3bb356f1/evidence-check-fads1-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The NutriCare | INFINITY DNA-Test by MyBody-X is marketed as a combo test for nutrition and skin. It includes SNPs like FADS1 rs174547 (omega-3 conversion), collagen-related variants, or antioxidant genes. Evidence for individual SNPs is mostly human-moderate (GWAS) or mechanistic, with small effect sizes. Lifestyle factors (diet, sun protection, skincare) dominate skin health. The test is not a medical device and cannot diagnose skin conditions under German GenDG. Results may offer general insights but should not replace a dermatologist. Overall evidence is mixed: some SNPs have moderate support, but the test's marketing claims often exceed the science. Sources: none from provided context.","area":"gesundheit","canonical_id":"gesundheit:canonical-370d9be6ad2f3f92d3830e0d","id":"public-16414e8a8cff02092b206c8f","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: NutriCare | INFINITY DNA-Test in the context of Haut","score":20.39213722,"snippet":"The NutriCare | INFINITY DNA-Test by MyBody-X is marketed as a combo test for nutrition and skin. It includes SNPs like FADS1 rs174547 (omega-3 conversion), collagen-related variants, or antioxidant genes. Evidence for individual SNPs is mostly human-moderate (GWAS) or mechanistic, with small effect sizes. Lifestyle factors (diet, sun protection, skincare) dominate skin health. The test is not a medical device and cannot diagnose skin conditions under German GenDG. Results may offer general insights but should not replace a dermatologist. Overall evidence is mixed: some SNPs have moderate support, but the test's marketing claims often exceed the science. Sources: none from provided context.","sources":[],"title":"Evidence check: NutriCare | INFINITY DNA-Test in the context of Haut","url":"https://tikki.wiki/wissen/gesundheit/frage/public-16414e8a8cff02092b206c8f/evidence-check-nutricare-infinity-dna-test-in-the-context-of-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"Based on the provided context, there is no direct evidence that a Cardio Risk Check can help with skin (Haut) issues. The context includes information on FADS1 variants affecting omega-3 metabolism, an IgE allergy test, and a nutrient deficiency panel, but none describe a specific 'Cardio Risk Check' or its relevance to dermatology. In general, cardiovascular risk factors such as inflammation, oxidative stress, and poor circulation can influence skin aging and conditions like acne or eczema. However, a typical cardio risk test (e.g., lipid panel, hs-CRP) is not designed to diagnose or guide treatment for skin disorders. The evidence for a direct benefit is unclear. Consumers should be aware that such tests are screening tools, not diagnostic. For skin concerns, targeted dermatological or allergological evaluation is more appropriate.","area":"gesundheit","canonical_id":"gesundheit:canonical-2d8e8ebe6e675e9265ebdecf","id":"public-e5ad009a1891b8b34ec9e1d3","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Can Cardio Risk Check help with Haut?","score":19.94062906,"snippet":"Based on the provided context, there is no direct evidence that a Cardio Risk Check can help with skin (Haut) issues. The context includes information on FADS1 variants affecting omega-3 metabolism, an IgE allergy test, and a nutrient deficiency panel, but none describe a specific 'Cardio Risk Check' or its relevance to dermatology. In general, cardiovascular risk factors such as inflammation, oxidative stress, and poor circulation can influence skin aging and conditions like acne or eczema. However, a typical cardio risk test (e.g., lipid panel, hs-CRP) is not designed to diagnose or guide treatment for skin disorders. The evidence for a direct benefit is unclear. Consumers should be aware ","sources":[],"title":"Can Cardio Risk Check help with Haut?","url":"https://tikki.wiki/wissen/gesundheit/frage/public-e5ad009a1891b8b34ec9e1d3/can-cardio-risk-check-help-with-haut/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The query on skin aging in women is outside the provided knowledge context, which mainly covers male hormone tests and a few DNA fragments (ALDH2, TAS2R38, GPX1, FADS1, ADIPOQ). Skin aging is multifactorial: declining estrogen during menopause, UV exposure, collagen loss, genetic predisposition (e.g., MC1R, COL1A1, SOD2), and lifestyle. Consumer DNA tests like MyBody-X may theoretically detect variants in these genes, but evidence for actionable recommendations is weak. Most studies are mechanistic or observational; randomized interventions are lacking. Moreover, environmental factors (sunscreen, diet, smoking) dominate the genetic component. A hormone check (like the male test in the context) is not directly transferable to women – female hormone profiles (estradiol, progesterone, SHBG) need separate assessment. Conclusion: Without specific study data, the predictive value is limited. Consumers should not make drastic changes based solely on a genetic test. A dermatologist or endocrinologist can provide a sound evaluation.","area":"gesundheit","canonical_id":"gesundheit:canonical-b0a1a85f406717507b9bf106","id":"public-0680d17733134981a80d517a","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"MyBody-X angle on Hautalterung Frauen","score":18.94706546,"snippet":"The query on skin aging in women is outside the provided knowledge context, which mainly covers male hormone tests and a few DNA fragments (ALDH2, TAS2R38, GPX1, FADS1, ADIPOQ). Skin aging is multifactorial: declining estrogen during menopause, UV exposure, collagen loss, genetic predisposition (e.g., MC1R, COL1A1, SOD2), and lifestyle. Consumer DNA tests like MyBody-X may theoretically detect variants in these genes, but evidence for actionable recommendations is weak. Most studies are mechanistic or observational; randomized interventions are lacking. Moreover, environmental factors (sunscreen, diet, smoking) dominate the genetic component. A hormone check (like the male test in the contex","sources":[],"title":"MyBody-X angle on Hautalterung Frauen","url":"https://tikki.wiki/wissen/gesundheit/frage/public-0680d17733134981a80d517a/mybody-x-angle-on-hautalterung-frauen/","verification":{"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"source_identity_verified":false,"tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}