MyBody-X angle on FTO Ernährung

The FTO gene (e.g., rs9939609) is the most robustly replicated obesity-associated locus from GWAS. The risk allele (A) increases BMI by about 0.3–0.5 kg/m² per allele, primarily through increased appetite and preference for energy-dense foods. MyBody-X may test this variant, but the effect size is modest; lifestyle factors account for the majority of weight variation. Evidence for personalized nutrition based on FTO is limited: some studies suggest higher protein or fiber intake may attenuate the genetic risk, but findings are inconsistent. A consumer FTO test is not diagnostic and should not be used to prescribe a specific diet. Marketing claims of an 'FTO diet' are not supported by strong evidence. The test can raise awareness of a predisposition, but weight management still relies on established lifestyle interventions. Consumers should be cautious about overinterpreting results and seek professional guidance for meaningful changes.