Evidence check: COMT in the context of Sport

COMT (catechol-O-methyltransferase) is an enzyme that breaks down neurotransmitters like dopamine. The common variant rs4680 (Val158Met) has been studied in relation to pain tolerance, stress response, and cognitive performance. In sports, some candidate gene and GWAS studies suggest that the Met/Met genotype may be associated with higher pain sensitivity but also better endurance performance. However, effect sizes are small, findings are inconsistent, and the evidence is insufficient for individual training or nutrition recommendations. MyBody-X tests provide genetic information only, not a diagnosis. Adjusting training solely based on COMT genotype is not evidence-based. Athletes should rely on proven training principles and medical advice.