{"count":2,"index":{"built_at":"2026-07-28T19:19:10.733897+00:00","public_records":70263,"revision":"4db6d26b3c449255bf596dd5"},"query":{"area":null,"kind":null,"lang":null,"limit":10,"match_mode":"all_terms","q":"Evidence check: COMT in the context of Sport"},"results":[{"answer":"COMT (catechol-O-methyltransferase) is an enzyme that breaks down neurotransmitters like dopamine. The common variant rs4680 (Val158Met) has been studied in relation to pain tolerance, stress response, and cognitive performance. In sports, some candidate gene and GWAS studies suggest that the Met/Met genotype may be associated with higher pain sensitivity but also better endurance performance. However, effect sizes are small, findings are inconsistent, and the evidence is insufficient for individual training or nutrition recommendations. MyBody-X tests provide genetic information only, not a diagnosis. Adjusting training solely based on COMT genotype is not evidence-based. Athletes should rely on proven training principles and medical advice.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-86fb49f8d99df5491269f7f9","id":"public-635ab4b01b299fea3b889b4b","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: COMT in the context of Sport","research_origin_label":"","score":25.31292493,"snippet":"COMT (catechol-O-methyltransferase) is an enzyme that breaks down neurotransmitters like dopamine. The common variant rs4680 (Val158Met) has been studied in relation to pain tolerance, stress response, and cognitive performance. In sports, some candidate gene and GWAS studies suggest that the Met/Met genotype may be associated with higher pain sensitivity but also better endurance performance. However, effect sizes are small, findings are inconsistent, and the evidence is insufficient for individual training or nutrition recommendations. MyBody-X tests provide genetic information only, not a diagnosis. Adjusting training solely based on COMT genotype is not evidence-based. Athletes should re","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: COMT in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-635ab4b01b299fea3b889b4b/evidence-check-comt-in-the-context-of-sport/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}},{"answer":"The query concerns a 'Hormoncheck Frauen' (women's hormone check) in the context of sports. The provided knowledge context contains no direct evidence for this specific test. Entries such as Fitness LifestyleCheck, COMT, and MTHFR indicate that many direct-to-consumer (DTC) tests overstate their utility. A women's hormone check might measure estrogen, progesterone, cortisol, or thyroid hormones. However, evidence for using such profiles to meaningfully guide training or nutrition is weak. Hormone levels fluctuate with menstrual cycle phase and time of day; single measurements are poorly predictive. Validated reference ranges for female athletes are lacking. Therefore, the evidence level is rated as 'marketing' or 'unclear'. Consumers should approach such tests critically and avoid making medical or performance decisions without professional oversight.","answer_eligible":false,"area":"gesundheit","canonical_id":"gesundheit:canonical-f4a3c7bcb318f3e224544bdd","id":"public-5f8a9354ebdf4c7e1a8e1f0c","kind":"qa","language":"en","publication_status":"existing_native_answer_privacy_screened_sources_pending","question":"Evidence check: Hormoncheck Frauen in the context of Sport","research_origin_label":"","score":23.5887424,"snippet":"The query concerns a 'Hormoncheck Frauen' (women's hormone check) in the context of sports. The provided knowledge context contains no direct evidence for this specific test. Entries such as Fitness LifestyleCheck, COMT, and MTHFR indicate that many direct-to-consumer (DTC) tests overstate their utility. A women's hormone check might measure estrogen, progesterone, cortisol, or thyroid hormones. However, evidence for using such profiles to meaningfully guide training or nutrition is weak. Hormone levels fluctuate with menstrual cycle phase and time of day; single measurements are poorly predictive. Validated reference ranges for female athletes are lacking. Therefore, the evidence level is r","source_count":0,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","sources":[],"title":"Evidence check: Hormoncheck Frauen in the context of Sport","url":"https://tikki.wiki/wissen/gesundheit/frage/public-5f8a9354ebdf4c7e1a8e1f0c/evidence-check-hormoncheck-frauen-in-the-context-of-sport/","verification":{"answer_eligible":false,"claim_support_verified":false,"human_reviewed":false,"quote_exact_match":false,"research_origin_label":"","source_identity_verified":false,"source_index_status":"pending","source_note":"Allgemeine Recherche; noch keine Quellen indexiert.","tier":"existing_native_answer_privacy_screened_sources_pending"}}],"schema_version":"tikki.search-response.v1"}