Evidence check: Progesteron in the context of Wechseljahre

Progesterone is commonly used in menopause as part of hormone replacement therapy (HRT), primarily combined with estrogen to reduce endometrial hyperplasia risk. Evidence for relief of hot flashes and sleep disturbances is moderate, mostly from observational studies and clinical practice. Recent research suggests benefits for bone density and cognitive function, but results are mixed. Crucially, individual risk-benefit assessment is essential, as progesterone can cause side effects like mood swings or fatigue. Use should always be medically supervised. Genetic testing for progesterone receptor variants (e.g., PGR) is not currently validated for clinical decision-making. The overall evidence level is 'human-moderate' due to limited randomized controlled trials. Consumers should not rely solely on DNA tests but seek professional medical advice.