Evidence check: VDR in the context of Müdigkeit

The link between VDR (vitamin D receptor) and fatigue is not well established. VDR mediates vitamin D activity, and vitamin D deficiency is associated with fatigue, low energy, and muscle weakness. However, direct evidence linking specific VDR gene variants (e.g., rs2228570, rs1544410) to fatigue is limited and inconsistent. Most studies are observational or mechanistic; no robust clinical trials confirm a causal role. Consumer genetic tests often overstate such associations. A clinical vitamin D test is more informative than genotyping. Supplementation should only follow confirmed deficiency. Overall, the evidence for VDR variants causing fatigue is weak to unclear. Clinical relevance is low.