Is IgE useful for fertility?

Whether IgE is useful for fertility is not supported by strong evidence. IgE antibodies are primarily involved in allergic responses. Some research suggests a possible link between allergies and fertility issues—e.g., through chronic inflammation or altered immune responses in the endometrium. However, the data are conflicting and mostly from observational studies. An IgE test, like those offered by MyBody-X, measures sensitization, not clinical allergy or a direct cause of infertility. False positives are common. Therefore, IgE testing is not recommended as a fertility diagnostic without medical context. Anyone with specific fertility concerns should consult a reproductive specialist. The evidence for IgE's utility in fertility is unclear.