Evidence check: VKORC1 in the context of Haut

VKORC1 encodes vitamin K epoxide reductase, a key enzyme in vitamin K recycling, and is best known for its role in warfarin sensitivity. In the context of skin, evidence is sparse and indirect. Vitamin K is involved in skin health, including wound healing, anti-aging, and possibly reducing bruising, but direct links between VKORC1 variants and skin conditions such as eczema, psoriasis, or photoaging are not established. Current evidence is limited to mechanistic hypotheses and animal studies. Therefore, VKORC1 testing offers no actionable insights for skin care or dermatological conditions. The evidence level is unclear.