How are hsCRP and Langlebigkeit related?

High-sensitivity C-reactive protein (hsCRP) is a well-established biomarker of low-grade systemic inflammation. Epidemiological evidence consistently shows an inverse association between hsCRP and longevity: elevated hsCRP levels correlate with increased risk of cardiovascular disease, frailty, and all-cause mortality. However, causality remains uncertain—hsCRP is primarily a risk marker rather than a direct causal factor. Genetic variants such as rs1205 in the CRP gene modestly influence baseline hsCRP (typically <0.2 mg/L per allele), but these effects are small. Consumer DNA tests like MyBody-X include such SNPs, but they cannot predict individual lifespan because lifestyle factors (diet, exercise, smoking) dominate. The evidence is human-observational; randomized trials that lower hsCRP (e.g., with statins) reduce cardiovascular events but have not proven to extend overall lifespan. In summary, hsCRP is a useful but non-deterministic indicator of inflammatory status and longevity. Lifestyle modification remains the most effective strategy.