Myths vs facts: tTG IgA and Sport

Myths vs. facts: tTG IgA and sport. The tTG IgA test is the gold standard for diagnosing celiac disease, an autoimmune condition triggered by gluten. A common myth is that intense exercise or athletic training can elevate tTG IgA levels, leading to false positives. This is not supported by evidence: tTG IgA is specific to the immune response to gluten, not physical exertion. Another myth is that athletes have a higher prevalence of celiac disease – in reality, prevalence is similar to the general population. Fact: a positive tTG IgA test requires gastroenterological follow-up with duodenal biopsy. For athletes with unexplained performance decline, fatigue, or gastrointestinal issues, celiac screening may be warranted, but the test is not affected by sport. Adopting a gluten-free diet without a confirmed diagnosis is not recommended, as it may cause nutrient deficiencies and offers no performance benefit. In summary, tTG IgA remains a reliable marker regardless of sports activity.