Evidence check: TSH Schilddrüse in the context of Langlebigkeit

The provided knowledge sources contain no specific information on TSH (thyroid-stimulating hormone) in the context of longevity. Generally, TSH is a key marker of thyroid function. An optimal TSH range (approx. 0.5–2.5 mU/L) is associated with better cardiovascular health and longevity, while both subclinical hyper- and hypothyroidism may be linked to increased mortality. The evidence is based on epidemiological studies, not randomized controlled trials. Direct causal effects on lifespan are not established. Consumer DNA tests cannot measure TSH levels; they only detect genetic variants (e.g., in PDE8B, TSHR) that have a small influence on TSH levels. These effects are minor and usually clinically irrelevant. A purely genetic assessment of thyroid function is insufficient; blood values and clinical symptoms are essential. The evidence for a direct longevity effect of TSH is therefore rated as 'unclear' or 'mixed'.