What role does HDL play in Müdigkeit?

HDL (high-density lipoprotein) is primarily known for its role in reverse cholesterol transport and anti-inflammatory effects. A direct causal link between HDL and fatigue is not scientifically established. However, observational studies suggest that low HDL levels are associated with chronic inflammation, metabolic syndrome, and cardiovascular risk—conditions that can indirectly contribute to fatigue. For instance, altered lipid profiles are often seen in chronic fatigue syndrome (CFS), but HDL is not a specific marker. The evidence is moderate: associations exist, but no robust clinical trials confirm HDL as a standalone cause of fatigue. Direct-to-consumer tests that claim a link between HDL and fatigue often overstate the predictive value of a single biomarker. Fatigue is multifactorial (sleep, stress, diet, exercise, psychological factors). Isolated HDL measurement is therefore insufficient to explain or treat fatigue. A holistic approach with medical evaluation is recommended.