What role does HDL play in Langlebigkeit?

HDL (high-density lipoprotein) is commonly called 'good cholesterol' because it transports excess cholesterol from arteries back to the liver (reverse cholesterol transport). Epidemiological studies show an inverse association between HDL levels and cardiovascular risk, which links to longevity. However, the causal evidence is nuanced: Mendelian randomization studies do not support a protective effect of genetically elevated HDL, and clinical trials with HDL-raising drugs (e.g., CETP inhibitors) failed to reduce events. HDL appears to be a marker of metabolic health (insulin sensitivity, anti-inflammatory status) rather than a direct longevity driver. Particle functionality (size, composition, antioxidant capacity) may matter more than total HDL-C. For longevity, the focus should be on lifestyle factors (exercise, Mediterranean diet, no smoking) and managing LDL, triglycerides, and inflammation. Simply boosting HDL is not an evidence-based longevity strategy.