Pharmakogenetik Medicheck: which supplements make sense?

The question of which supplements make sense based on a pharmacogenetics test like MyBody-X's Medicheck requires a realistic assessment. Evidence for most gene–supplement interactions is weak. While some well-validated gene–drug interactions exist (e.g., CYP2C9 with vitamin K antagonists, TPMT with thiopurines, SLCO1B1 with statins), supplement recommendations from consumer tests are generally not clinically validated. Common claims involve MTHFR variants and folate, COMT and methyl donors, or VDR and vitamin D. However, effect sizes are often small, the literature is conflicting, and lifestyle factors dominate. MyBody-X itself disclaims medical use. From an evidence-based perspective, only a few supplements are clearly indicated: vitamin D if deficiency is confirmed by blood test (not genotype), folic acid for women planning pregnancy (regardless of MTHFR), and possibly omega-3 fatty acids if dietary intake is low. A PGx test may offer hints but does not replace medical advice. Be cautious of high doses or expensive personalized blends without proof. Safety note: Do not stop or change any medication without consulting a physician.