hsCRP (high-sensitivity C-reactive protein) is a well-established marker of systemic inflammation. Chronically mildly elevated levels (0.5–2 mg/L) are associated in observational studies with higher risk of cardiovascular disease and premature aging. However, hsCRP is not a direct longevity test: it measures inflammation, not the biological aging rate itself. The evidence comes mostly from epidemiological studies; randomized controlled trials proving that lowering hsCRP extends lifespan are lacking. Moreover, hsCRP is strongly influenced by acute infections, smoking, obesity, and physical inactivity. A single value says little about individual longevity. Repeated measurement in the context of other biomarkers (e.g., HbA1c, lipids) and lifestyle factors is more meaningful. Genetics (e.g., rs1205) have only a minor effect on hsCRP and are not clinically actionable. Conclusion: hsCRP can be useful as part of an inflammation-based health screening, but not as a standalone predictor of longevity.
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