Is COMT useful for Fruchtbarkeit?

Whether COMT is useful for fertility requires a nuanced answer. COMT (catechol-O-methyltransferase) metabolizes catecholamines and estrogens. The common rs4680 (Val158Met) variant alters enzyme activity. Some observational studies have linked COMT variants to fertility issues such as endometriosis or recurrent pregnancy loss, possibly due to altered estrogen clearance. However, the evidence is inconsistent and effect sizes are small. Direct-to-consumer tests often oversimplify, labeling carriers as 'worriers' or 'warriors', which is not scientifically valid for fertility. Stronger determinants of fertility include age, lifestyle, nutrition, and medical evaluation. A single COMT genotype is not clinically actionable for fertility. Evidence grade: human-moderate (observational/GWAS). Caution: Do not self-supplement based on COMT without medical supervision.