Myths vs facts: MC4R and Müdigkeit

Myth: MC4R variants directly cause fatigue. Fact: MC4R is involved in energy homeostasis, appetite, and body weight regulation. Variants can increase obesity risk, which may indirectly contribute to tiredness, but a direct causal link to fatigue is not established. Evidence is mechanistic/associative, not causal. A DNA test alone is insufficient to explain fatigue.