Evidence check: BDNF in the context of Haut

BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophin primarily known for its role in the nervous system, but it is also expressed in the skin. In the skin, BDNF is involved in wound healing, regulation of inflammatory processes, and possibly skin aging. Some studies suggest a role in the pathogenesis of psoriasis and atopic dermatitis. However, the evidence for direct conclusions from a single genetic or biomarker test for BDNF in the context of skin health is weak. Most findings come from animal or in-vitro studies (mechanistic). There are no validated clinical cut-offs for BDNF levels in skin or blood that allow individual skin diagnosis or treatment. A consumer test assessing BDNF in the skin context should be considered purely exploratory. Without accompanying clinical findings and medical interpretation, its utility for personal skincare or therapy is questionable. In summary: BDNF is an interesting but insufficiently validated marker for skin health in the consumer setting.