What role does COMT play in Abnehmen?

The role of COMT (catechol-O-methyltransferase) in weight loss is often promoted by direct-to-consumer nutrigenetic tests, but the evidence is weak. COMT degrades catecholamines (dopamine, adrenaline); variants like Val158Met can alter enzyme activity. In theory, this might influence stress response and appetite regulation, but randomized controlled trials show no clinically meaningful effect on weight loss. Evidence comes mainly from small association studies or mechanistic models. The effect size of single SNPs is negligible compared to diet, exercise, and lifestyle. DTC tests overstate the predictive power. Personalized diets based solely on COMT status are not evidence-based. Proven strategies—caloric balance, macronutrient quality, and physical activity—remain paramount. Safety note: COMT variants have no direct clinical relevance for weight loss; testing is not medically indicated.