warum nehme ich nicht ab — what are common causes?

The question of why you are not losing weight is multifactorial, and the provided context (CYP1A2, microbiome, APOE, blood pressure SNPs) does not directly address weight loss with strong evidence. Common causes include: persistent caloric surplus (even from hidden calories in drinks or snacks), insufficient physical activity, poor sleep quality, chronic stress (elevated cortisol promotes fat storage), hormonal imbalances (e.g., hypothyroidism, insulin resistance), and medications (antidepressants, beta-blockers). Metabolic adaptation after dieting can lower resting energy expenditure. Consumer DNA tests like MyBody-X may touch on caffeine metabolism (CYP1A2) or lipid metabolism (APOE), but these are minor pieces of a larger puzzle. The evidence for direct 'weight loss genes' is weak; most effects are polygenic and small. Without a medical workup (blood panel, thyroid, fasting glucose) and an honest assessment of diet and activity, any genetic interpretation remains speculative. Safety note: If weight loss stalls or weight increases despite efforts, consult a physician to rule out underlying medical conditions.