Whether FUT2 (fucosyltransferase 2) is useful for skin health is not well supported by current evidence. FUT2 determines secretor status and influences gut microbiome composition and vitamin B12 absorption. Some mechanistic research suggests a link between the gut microbiome and skin (gut-skin axis), so FUT2 variants could theoretically affect skin conditions like acne or eczema indirectly via microbiota. However, robust clinical studies demonstrating a direct, reproducible effect of FUT2 on skin are lacking. The evidence is best rated as 'mechanistic' or 'unclear'. Direct-to-consumer tests that use FUT2 for skin recommendations often overstate its predictive value. For specific skin concerns, consulting a dermatologist is more appropriate than relying on SNP-based advice.
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