What to watch with Ferritin Eisenmangel and longevity?

Ferritin is a key marker of body iron stores. Iron deficiency (low ferritin) can impair mitochondrial function, reduce oxygen delivery, and cause chronic fatigue—factors that may shorten healthspan. Conversely, high ferritin (iron overload) promotes oxidative stress and is linked to aging-related diseases like atherosclerosis and neurodegeneration. For longevity, an optimal, non-extreme ferritin level appears beneficial. Studies show both anemia and hemochromatosis increase mortality risk. However, a single ferritin value is insufficient; it must be interpreted alongside transferrin saturation, CRP (inflammation), and clinical context. Consumer tests have limitations: ferritin is an acute-phase reactant, so inflammation can falsely elevate it, masking deficiency. For longevity, aim for mid-range ferritin (approx. 50–150 µg/L for women, 70–200 µg/L for men) and monitor regularly with a physician. Evidence: human-moderate (epidemiological studies on iron status and mortality).