What to watch with Pharmakogenetik Medicheck and fertility?

When combining pharmacogenetics (e.g., MyBody-X Medicheck) with fertility, caution is warranted: most direct-to-consumer tests are not approved for diagnosis or treatment guidance. Genetic variants relevant to fertility (e.g., MTHFR, F5, CYP isoenzymes) often have weak or conflicting evidence. In particular, MTHFR polymorphisms are frequently linked to miscarriage, but current guidelines (ACMG, CDC) advise against routine MTHFR testing and recommend folic acid over methylfolate. For dosing of fertility drugs (clomiphene, letrozole) or anticoagulants during IVF, no validated genetic algorithms exist. Some medications (e.g., antidepressants, antiepileptics) are metabolized by CYP enzymes, and genotype can affect drug levels – but without medical supervision, this may lead to incorrect dosing. Bottom line: pharmacogenetics can offer hints but should not be the sole basis for decisions. Consult a reproductive specialist and do not rely on lay interpretations of DTC tests.