Myths vs facts: Folsäure and longevity

The question of folic acid and longevity is a classic case of myth versus fact. Folic acid (vitamin B9) is essential for DNA synthesis and homocysteine reduction, a risk factor for cardiovascular disease. Observational studies suggest an association between low folate status and higher mortality, but randomized controlled trials (RCTs) have not demonstrated a clear benefit of supplementation for extending lifespan in healthy individuals. In fact, high doses (≥1 mg/day) may promote tumor growth in people with pre‑existing lesions. The provided context contains no specific data on folic acid and longevity. Therefore, the evidence is 'mixed': plausible mechanisms exist, but robust proof of life extension is lacking. Supplementation is well‑justified for pregnant women and those with confirmed deficiency. Consumers should not rely on DNA tests or blanket advice; instead, they should have blood markers (e.g., homocysteine, folate) evaluated by a clinician.