How are AMH and fatigue related?

The direct relationship between AMH (anti-Müllerian hormone) and fatigue is not well established in scientific literature. AMH is primarily used as a marker of ovarian reserve in fertility assessment, not as a diagnostic tool for general fatigue. Low AMH may indicate perimenopause, which can involve fatigue due to hormonal fluctuations, but this is an indirect association. No high-quality studies confirm AMH as a reliable predictor of fatigue. Other causes such as thyroid dysfunction, iron deficiency, vitamin D levels, or sleep disorders are far more relevant. Testing AMH solely for fatigue is not evidence-based. The evidence is mechanistic and observational at best. Caution: a normal AMH does not rule out hormone-related fatigue, and a low AMH does not guarantee fatigue. Clinical evaluation should focus on comprehensive history and targeted lab work.