CRP (C-reactive protein) is a well-established marker of systemic inflammation measured in blood. Chronic psychological stress can promote a pro-inflammatory state via sympathetic activation and HPA axis dysregulation, which may elevate CRP levels. Observational studies show modest associations between perceived stress and higher CRP, but CRP is not a specific 'stress test'. Levels are also influenced by infections, smoking, obesity, sleep deprivation, and diet. Therefore, while an elevated CRP can hint at stress-related inflammation, it does not diagnose stress itself. For meaningful interpretation, repeated measurements and lifestyle context are needed. MyBody-X offers CRP testing as part of inflammation or wellness panels, but explicitly states these are not medical diagnostics. The evidence for using CRP specifically to assess stress is mechanistic: the biological link is plausible, but clinical utility for stress management is not established. Caveat: Do not use CRP alone to gauge stress; consider cortisol, sleep, diet, and psychosocial factors for a comprehensive picture.
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