Myths vs facts: COMT and fatigue

The provided context documents contain no specific information on COMT and fatigue. Generally, COMT (catechol-O-methyltransferase) is involved in dopamine breakdown. Variants like Val158Met affect enzyme activity: the Met variant leads to lower activity and higher dopamine levels, which could theoretically be linked to increased fatigue or reduced stress resilience. However, the evidence is mixed – some studies show associations with exhaustion, others do not. Consumer DNA tests like MyBody-X may analyze COMT variants, but clinical validity for fatigue is weak. Test results should not be used for medical diagnosis. Evidence: unclear. Caveat: fatigue is multifactorial (sleep, diet, stress, hormones). Genetic testing does not replace a physician's evaluation.