Is Progesteron useful for Langlebigkeit?

The question of whether progesterone is useful for longevity lacks robust scientific evidence. Progesterone is a key steroid hormone involved in the menstrual cycle, pregnancy, and has additional roles in neuroprotection, anti-inflammation, and bone health—mechanisms that could theoretically influence aging. However, no high-quality human studies demonstrate that progesterone supplementation extends lifespan or delays aging. Animal studies show mixed results, with some suggesting modest lifespan extension, but these findings are not directly translatable to humans. In clinical practice, progesterone is used in hormone replacement therapy (HRT) for postmenopausal women, often combined with estrogen, to manage symptoms and reduce certain risks, but its long-term effects on longevity are unclear. Moreover, unguided use carries risks, including potential cardiovascular and cancer concerns. The evidence level is mechanistic/unclear. For longevity, proven interventions like caloric restriction, exercise, and sleep hygiene are far more reliable. Any hormone therapy should be discussed with a physician based on individual health status, not as an anti-aging panacea.