What to watch with CYP2D6 and longevity?

CYP2D6 is a key drug-metabolizing enzyme, not a longevity gene. Claims linking CYP2D6 variants directly to lifespan lack solid evidence. Some indirect connections are discussed—e.g., via metabolism of hormones or neurotransmitters—but effect sizes are tiny and overshadowed by lifestyle. In practice, your CYP2D6 status determines how you process many common drugs (beta-blockers, antidepressants, opioids). Poor metabolizers risk toxicity; ultra-rapid metabolizers may get no benefit. Longevity, however, is highly polygenic and dominated by diet, exercise, and environment. A CYP2D6 test is useful for pharmacogenetics, not for predicting how long you'll live. Always consult a healthcare professional before adjusting medications based on your genotype. Evidence: mechanistic, no validated longevity associations.