What to watch with Folsäure and Fruchtbarkeit?

When it comes to folic acid and fertility, the key is balance. The standard recommendation of 400 µg per day for women planning pregnancy is well-established to prevent neural tube defects. However, many DNA tests (e.g., for MTHFR variants) push high-dose folic acid, yet randomized controlled trials do not support a clear benefit for general fertility. In fact, excessive folic acid (above 1 mg) may mask vitamin B12 deficiency and has been linked to potential risks. For those with MTHFR variants, conversion of synthetic folic acid to active folate is impaired, so methylfolate or folate-rich foods (kale, spinach, legumes) may be more appropriate. Watch out for over-supplementation: more is not better. The evidence for folic acid directly improving fertility (e.g., ovulation) is moderate at best; its primary role is in early pregnancy. Always consult a healthcare provider before taking high doses, and consider a balanced diet first.