Evidence check: Menopause Check in the context of Haut

A Menopause Check in the context of skin is a commercial test that typically analyzes genetic markers such as rs1799750 (MMP1) or MC1R. These markers have mechanistic evidence linking them to collagen breakdown and UV sensitivity, but the evidence for predicting skin changes during menopause is weak. Menopause itself causes hormonal shifts (estrogen decline) that affect skin aging, dryness, and collagen loss – a genetic test cannot capture these complex processes. Lifestyle factors like sun protection, nutrition, and overall health are far more impactful. Such tests are not clinically validated and should not be used for diagnosis or treatment decisions. The evidence is mostly mechanistic or from GWAS with small effect sizes. Be cautious of exaggerated marketing claims that promise direct benefits for skin health. Consulting a healthcare provider about hormone therapy or skincare is more evidence-based than relying on a single genetic test.