Is tTG IgA useful for Abnehmen?

The tTG IgA test (tissue transglutaminase antibodies) is a well-established screening marker for celiac disease, an autoimmune condition triggered by gluten. Untreated celiac disease can cause malabsorption and unintentional weight loss. Therefore, the test is useful when celiac disease is suspected—e.g., with chronic digestive issues, fatigue, or nutrient deficiencies. However, for intentional weight loss (Abnehmen), the test is not directly useful. Evidence for its diagnostic accuracy in celiac disease is strong (human-strong), but a positive result does not mean a gluten-free diet will lead to weight loss. In fact, many people without celiac disease gain weight on gluten-free products because they are often higher in calories. The test should only be performed with clinical suspicion and under medical guidance. A negative result largely rules out celiac disease but says nothing about other causes of overweight. For general weight loss, calorie balance, exercise, and individual metabolic factors are key—not a single antibody test.