How are Folsäure and Wechseljahre related?

The relationship between folic acid and menopause is complex but not strongly evidence-based. Folic acid (vitamin B9) is crucial for DNA synthesis, cell division, and homocysteine metabolism. During menopause, cardiovascular risk increases, and elevated homocysteine is an independent risk factor. Some studies suggest adequate folate status may lower homocysteine and possibly alleviate hot flashes or mood swings—but effects are small and inconsistent. Folic acid is often discussed in the context of MTHFR gene variants: carriers of the C677T variant have reduced enzyme activity and might theoretically benefit from active folate (5-MTHF). However, the benefit of supplementation in menopause is not supported by large RCTs. Most recommendations are based on observational studies or extrapolations from pregnancy. For individual advice, blood markers (homocysteine, folate) are more informative than genetic tests. Beware of exaggerated marketing claims: folic acid is not an anti-aging remedy. Evidence: human-moderate.