What to watch with hsCRP and menopause?

HsCRP (high-sensitivity C-reactive protein) is an inflammatory marker that can rise during menopause due to declining estrogen, which has anti-inflammatory effects. This increase contributes to higher cardiovascular risk post-menopause. An hsCRP level >2 mg/L suggests low-grade chronic inflammation linked to atherosclerosis, insulin resistance, and metabolic syndrome. However, hsCRP is also elevated by acute infections, smoking, obesity, and stress, so repeated measurements are recommended. Lifestyle interventions such as a Mediterranean diet, regular exercise, and weight management can lower hsCRP. Hormone replacement therapy (HRT) may also reduce inflammation but requires individual risk-benefit assessment. Evidence is based on epidemiological and observational studies; randomized controlled trials are limited. HsCRP alone is not diagnostic but a risk indicator. Elevated levels warrant medical evaluation. Consumer DNA tests for hsCRP have limited utility because the marker is highly environment-dependent.