Is FUT2 useful for Langlebigkeit?

The question of whether FUT2 is useful for longevity cannot be answered affirmatively with current evidence. FUT2 encodes a fucosyltransferase that determines secretor status, influencing blood group antigens on mucosal surfaces. Known associations include vitamin B12 levels (non-secretors tend to have lower B12) and gut microbiome composition. Some GWAS link FUT2 variants to B12 deficiency, but direct, robust associations with lifespan or biological aging are lacking. The effects are small and confounded by diet, gut health, and other genetic factors. For evidence-based longevity guidance, FUT2 is not a primary marker. It is more practical to measure blood B12 and optimize gut microbiota through fiber and fermented foods. Using FUT2 alone to predict longevity remains speculative and unsupported by human studies.