Can tTG IgA help with Allergie?

tTG IgA (tissue transglutaminase IgA) is a well-established biomarker for celiac disease, an autoimmune condition triggered by gluten, not for allergies (which are typically IgE-mediated). While celiac disease can cause allergy-like symptoms such as bloating, diarrhea, or skin rashes, the test is not designed to diagnose allergies. For true allergies (e.g., pollen, food), specific IgE tests or skin prick tests are needed. A positive tTG IgA should be confirmed by duodenal biopsy before starting a gluten-free diet. Direct-to-consumer tests for tTG IgA may lack clinical validation. Caveat: A negative tTG IgA does not rule out celiac disease, especially in IgA-deficient individuals. If you suspect an allergy, consult an allergist rather than relying on this test.