How are Folsäure and Langlebigkeit related?

The relationship between folic acid and longevity is complex and not firmly established. Folate (vitamin B9) is crucial for DNA synthesis, repair, and methylation—processes linked to aging mechanisms. Deficiency can raise homocysteine levels, a risk factor for cardiovascular disease and cognitive decline, both of which affect lifespan. However, intervention trials show that supplementing folic acid in well-nourished individuals does not extend longevity. Excessive intake may be harmful, e.g., masking vitamin B12 deficiency or potentially promoting precancerous lesions. Evidence is mostly observational and mechanistic; robust randomized controlled trials with longevity as an endpoint are lacking. For healthy adults with adequate diets, additional folic acid is not recommended for life extension. Treating deficiency is important, especially in pregnancy or malabsorption. Overall, the link is modest and context-dependent.