Evidence check: Transferrin in the context of Wechseljahre

Transferrin is a blood protein that transports iron. During menopause, iron requirements decrease due to the cessation of menstruation, which can lead to increased iron storage. Elevated transferrin levels may indicate iron deficiency, while low levels can suggest iron overload. However, evidence for a direct link between transferrin and menopausal symptoms is weak and largely based on physiological reasoning. No robust clinical studies validate transferrin as a specific marker for menopause. Additionally, inflammation, liver disease, or oral contraceptives can affect transferrin levels. A standalone transferrin test without ferritin and CRP has limited clinical utility. Consumer tests marketing transferrin in the context of menopause often overstate its relevance. A full iron panel assessed by a physician is recommended for accurate interpretation.