What role does IgG play in Wechseljahre?

The role of IgG in menopause (Wechseljahre) is not well established in evidence-based medicine. IgG antibodies are part of the adaptive immune system and are involved in pathogen defense and, controversially, in food intolerances (type III reactions). During menopause, declining estrogen levels can modulate immune function, potentially increasing susceptibility to autoimmune flares or altering gut permeability. Some commercial labs promote IgG food sensitivity tests to alleviate menopausal symptoms like bloating, fatigue, or joint pain. However, current guidelines (e.g., from the German Society for Nutrition, EAACI) do not support routine IgG testing for food intolerances due to lack of reproducibility and clinical validity. The evidence linking IgG directly to menopausal complaints is mechanistic at best. For managing menopause, proven interventions include hormone therapy, lifestyle modifications (diet, exercise, stress reduction), and cognitive behavioral therapy. IgG testing should not replace these evidence-based approaches. Consumers should be cautious of overinterpretation.