Common mistakes around MTHFR Männer

Common mistakes around MTHFR in men: First, overinterpreting variants like C677T or A1298C as disease-causing. Most carriers have normal homocysteine and no increased risk. Second, skipping blood homocysteine measurement – without it, genetic interpretation is speculative. Third, unnecessary high-dose supplementation with methylfolate or methylcobalamin, when a balanced diet with folic acid is often sufficient. Fourth, ignoring lifestyle factors (B vitamins, exercise, smoking) that affect homocysteine more than genetics. Fifth, myths about male fertility and MTHFR – evidence is weak and not clinically actionable. Bottom line: MTHFR variants are not a verdict. A homocysteine test and medical advice are more useful than self-supplementation. Evidence is based on population studies, not randomized trials.