Menopause Check: what are common causes?

Menopause is defined as the permanent cessation of menstruation for 12 months due to loss of ovarian follicular activity. The most common cause is natural age-related ovarian depletion (average age 51). Other causes include: surgical removal of ovaries (bilateral oophorectomy), chemotherapy or pelvic radiation, primary ovarian insufficiency (before age 40), autoimmune disorders, genetic factors (e.g., FMR1 premutation), and metabolic conditions. The provided context does not cover menopause. Evidence for these causes is human-strong (epidemiological studies, clinical guidelines). Caveat: consumer DNA tests for menopause causes are not clinically validated; diagnosis relies on symptoms and hormone tests. Early menopause warrants medical evaluation.