IgG (Immunoglobulin G) is the most abundant antibody in blood and plays a key role in immune defense and immunological memory. In the context of longevity, IgG is primarily discussed in relation to chronic inflammation – a phenomenon known as 'inflammaging'. Chronically elevated IgG levels may indicate persistent immune activation, which is linked to aging processes and age-related diseases. However, the evidence is complex: some studies associate higher IgG levels in older adults with poorer health, while others suggest protective roles of specific IgG subclasses against infections. The provided context does not contain direct studies or data linking IgG to longevity. Therefore, the role of IgG as a longevity biomarker remains unclear. It is a mechanistic association that requires further research. Consumers should be cautious about interpreting IgG values from self-tests without medical guidance.
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