Myths vs facts: TSH Schilddrüse and Langlebigkeit

The relationship between TSH, thyroid function, and longevity is complex and often clouded by myths. Fact: TSH is a sensitive but indirect marker of thyroid status. Elevated TSH indicates hypothyroidism, which if untreated can increase cardiovascular risk and potentially shorten lifespan. However, mild TSH elevation (subclinical hypothyroidism) in older adults may not require treatment and has even been associated with lower mortality in some observational studies. The myth that an 'optimal' TSH of 1–2 mU/L directly extends lifespan is not supported by robust longitudinal or interventional data. Evidence is largely observational and mechanistic, not from randomized controlled trials. TSH is influenced by circadian rhythm, diet, stress, and medications. A single TSH value without free T3, T4, and antibodies is insufficient for longevity assessment. The direct link between TSH and longevity remains weak. Instead of chasing an ideal TSH number, clinical context, symptoms, and individual risk factors should guide decisions. The provided context does not contain specific information on TSH, thyroid, or longevity.