Evidence check: IgG in the context of Müdigkeit

IgG antibody testing for foods is often marketed for non-specific symptoms like fatigue, headaches, or bloating. The idea is that delayed immune reactions (Type III hypersensitivity) to certain foods cause chronic inflammation and exhaustion. However, this concept lacks solid scientific support. Mainstream medical societies, including the European Academy of Allergy and Clinical Immunology (EAACI), do not recommend IgG testing for food intolerance. The evidence is weak: no high-quality trials show that eliminating IgG-positive foods reliably reduces fatigue. In fact, IgG antibodies to foods are common in healthy individuals and merely reflect immune exposure, not disease. Relying on such tests can lead to unnecessary dietary restrictions, nutritional deficiencies, and delayed diagnosis of real underlying conditions. For persistent fatigue, evidence-based workups should include iron status, thyroid function, sleep disorders, and mental health assessment. IgG testing remains a marketing-driven tool with insufficient clinical validation.