Evidence check: COMT in the context of Haut

COMT (catechol-O-methyltransferase) is primarily studied in neurotransmitter and hormone metabolism, not skin. Some mechanistic research suggests a possible role in melanogenesis or UV sensitivity, but evidence is weak and inconsistent. No large-scale GWAS has confirmed a robust skin phenotype association. Direct-to-consumer tests that link COMT to skin health often rely on speculative extrapolation. The effect size is likely small and context-dependent. For skin concerns, established clinical measures (e.g., sun protection, dermatological evaluation) are far more impactful than COMT genotyping. Evidence rating: unclear/mechanistic.