Progesterone and sleep are linked through several mechanisms. Progesterone has a calming effect on the central nervous system by acting as an agonist at the GABA-A receptor, similar to benzodiazepines. This can reduce sleep onset latency and improve sleep quality. Additionally, progesterone influences breathing and may alleviate sleep apnea symptoms. However, the evidence is moderate: most studies are small or observational; large RCTs are lacking. In women, progesterone levels decline during menopause, which can contribute to sleep disturbances. Hormone replacement therapy with progesterone may help, but it is not suitable for everyone. The MyBody-X Women's Wellness Check does not directly measure progesterone but provides an overview of hormonal markers. Important: Progesterone supplements should only be taken under medical supervision due to risks like drowsiness or mood changes. Evidence grade: human-moderate.
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