What to watch with COMT and Fruchtbarkeit?

COMT (Catechol-O-Methyltransferase) is a key enzyme in the breakdown of estrogens and catecholamines. The common Val158Met variant affects enzyme activity: Met carriers have lower activity, potentially leading to higher estrogen levels. In fertility, this may matter because altered estrogen metabolism is linked to ovulatory dysfunction, endometriosis, or recurrent miscarriage. However, evidence is moderate – association studies exist, but no clinical guidelines recommend routine COMT testing for fertility. COMT also interacts with MTHFR (methylation), affecting homocysteine and folate metabolism, which are relevant for reproduction. Important: A COMT test alone does not predict fertility; it must be interpreted alongside hormone profiles, cycle parameters, and other genetic markers (e.g., MTHFR). Marketing often overstates its role. Consult a reproductive specialist before taking any action.