How are IgE and Langlebigkeit related?

The direct relationship between IgE and longevity is poorly supported by evidence. IgE is primarily involved in allergic responses and parasite defense. Chronic inflammation, including IgE-mediated pathways, is discussed as a driver of biological aging (oxidative stress, inflammaging). However, robust human studies confirming IgE levels as an independent longevity biomarker are lacking. Some observations in centenarians show altered immunoglobulin profiles, but without a specific IgE focus. The evidence is mostly mechanistic and insufficient for clinical recommendations. IgE testing for longevity assessment is currently not indicated.